# 028 Subcutaneous Opioid Infusions, 2nd ed


Author(s): David E Weissman MD

Background A parenteral opioid infusion is the standard of care for managing moderate-severe pain or dyspnea when the oral/rectal route is unavailable and/or frequent dose adjustments are needed. As death nears, the burden of maintaining intravenous (IV) access, especially in the home setting, can be enormous. An alternative delivery route is the subcutaneous (SQ) route for continuous infusions, Patient Controlled Analgesia (PCA), or intermittent bolus opioid injections.

Drugs Morphine, hydromorphone (Dilaudid), fentanyl, and sufentanil can all be safely administered as SQ bolus doses or continuous SQ infusion. Methadone infusions cause frequent skin irritation; one case series reported successful use of methadone with concurrent dexamethasone infusion and frequent site rotation.

Dosing equivalents Dose conversion ratios between the IV and SQ route for all the above listed opioids are not well established. For morphine, the ratio appears to be close to 1 mg IV = 1mg SQ.

Pharmacokinetics SQ infusions can produce the same blood levels as chronic IV infusions. There is no data to suggest that cachectic, febrile or hypotensive patients have problems with drug absorption.

Volume and Drug Choice The limiting feature of a SQ infusion is the infusion rate; in general, SQ tissue can absorb up to 3 ml/hr. At low opioid requirements morphine is generally the drug of choice based on availability and cost; a switch to hydromorphone is indicated for a high opioid requirement due its higher intrinsic potency (~6:1), thus the need for a smaller infusion volume.

Administration Use a 25 or 27 gauge butterfly needle—place on the upper arm, shoulder, abdomen or thigh. Avoid the chest wall to prevent iatrogenic pneumothorax during needle insertion. The needle can be left indefinitely without site change unless a local reaction develops—typically, patients can keep the same needle in place for up to one week at a time.

Toxicity Local skin irritation, itching, site bleeding or infection can occur. Of these, skin irritation is the most common, managed by a needle site change.

Patient acceptance Patients readily appreciate the ease of SQ administration as an alternative to IV access.


  1. Bruera E, Brenneis C, Michaud M, et al. Use of the subcutaneous route for the administration of narcotics in patients with cancer pain. Cancer. 1988; 62:407-411.
  2. Storey P. Subcutaneous infusion for control of cancer symptoms. J Pain Symptom Manage. 1990; 5:33-41.
  3. Waldman CS, Eason JR, Rambohul E, et al. Serum morphine levels—a comparison between continuous SQ and IV infusion in post-operative analgesia. Anaesthesia. 1984; 39:768-771.
  4. Mathew P, Storey P. Subcutaneous methadone in terminally ill patients: manageable local toxicity. J Pain Symptom Manage. 1999; 18:49-52.

Fast Facts and Concepts are edited by Drew A. Rosielle MD, Palliative Care Center, Medical College of Wisconsin. For more information write to: drosiell@mcw.edu. More information, as well as the complete set of Fast Facts, are available at EPERC: www.eperc.mcw.edu.

Version History: This Fast Fact was originally edited by David E Weissman MD. 2nd Edition published July 2005. Current version re-copy-edited March 2009.

Copyright/Referencing Information: Users are free to download and distribute Fast Facts for educational purposes only. Weissman DE. Subcutaneous Opioid Infusions, 2nd Edition. Fast Facts and Concepts. July 2005; 28. Available at: http://www.eperc.mcw.edu/EPERC/FastFactsIndex/ff_028.htm.

Disclaimer: Fast Facts and Concepts provide educational information. This information is not medical advice. Health care providers should exercise their own independent clinical judgment. Some Fast Facts cite the use of a product in a dosage, for an indication, or in a manner other than that recommended in the product labeling. Accordingly, the official prescribing information should be consulted before any such product is used.

ACGME Competencies: Medical Knowledge, Patient Care

Keyword(s): Pain – Opioids