Author(s): Gary M. Reisfield MD and George R Wilson MD
Background The sympathetic nervous system spans the length of the axial skeleton; most of the various plexi and ganglia are readily accessible to percutaneous interruption. In the palliative care setting, the most common indication for interrupting the sympathetic axis is to control pain arising from malignancies of the abdominal and pelvic viscera. Visceral pain is often described as constant, deep and is difficult to localize and characterize. When such a pain syndrome is recalcitrant to meticulous application of drug and behavioral therapy, or if the patient is intolerant to drug therapy, consultation should be sought for consideration of neurolytic procedures. Potential advantages of a neurolytic procedure, compared to spinal and epidural anesthetic techniques (see Fast Fact #98), include cost savings and avoidance of hardware (e.g. catheters, tubes, pump), which can be cumbersome, are subject to malfunction, and pose an infection risk.
Types of Blocks The following procedures have an established record of success in well-selected patients:
Celiac plexus block (CPB). Used for upper abdominal pain – most commonly from pancreatic cancer. It is also appropriate for pain involving the GI tract from the distal third of the esophagus to the transverse colon, the liver and biliary tract, the adrenals, and mesentery.
Superior hypogastric plexus block. Applicable to malignant pain of the gastrointestinal tract from the descending colon to the rectum, as well as the urogenital system.
Ganglion impar block. Pain involving the rectum and perineum.
Procedure For CPB, patients are positioned supine or prone, according to operator preference and patient comfort. Patients are intravenously hydrated and sedated. The skin and underlying tissues are infiltrated with local anesthesic. Neurolytic blocks are often preceded by local anesthetic blocks to assess adequacy of analgesic response before executing a neurodestructive procedure. In the palliative setting, local anesthetic blocks are often waived due to logistical and patient comfort issues. Neurolytic procedures are always performed under fluoroscopic, CT, or endoscopic ultrasound to minimize potential for damage to organs and spinal cord. Blocks are performed with ethyl alcohol (50-100%) or phenol (6-10%). Neurolytic blocks may provide several months of analgesia and may be repeated.
Complications & Side Effects Side effects – referable to loss of sympathetic tone – include transient hypotension and increased intestinal motility. Complications include needle injury to visceral, neural, and vascular structures; pain at the injection site; and failure to obtain an analgesic response. Contraindications to these procedures include bleeding diathesis and local infection.
Post-Procedural Management Crucial to the success of sympatholysis is proper patient selection and technical skill. Sympathetic blocks are not a panacea and generally do not obviate the need for ongoing pharmacological management of residual pain. However, they can substantially improve analgesia and quality of life, and may allow for opioid dosage reduction. Note: attempts at post-block opioid reduction should be done with care to avoid unmasking existing nociceptive/neuropathic pain and precipitating opioid withdrawal.
Waldman SD, ed. Interventional Pain Management. 2nd Edition. Philadelphia, PA: WB Saunders Company; 2001.
De Leon-Casasola OA. Critical evaluation of chemical neurolysis of the sympathetic axis for cancer pain. Cancer Control. 2000; 7(2):142-148.
Mercadante S, Nicosia F. Celiac plexus block: a reappraisal. Reg Anesth Pain Med. 1998; 23:37-48.
Trans QHN, et al. Endoscopic ultrasound-guided celiac plexus neurolysis for pancreatic cancer pain: a single-institution experience and review of the literature. J Supportive Oncol. 2006; 4(9):460-464.
Wang PJ, et al. CT-guided percutaneous neurolytic celiac plexus block technique. Abdominal Imaging. 2006; 31(6):710-718.
Fast Facts and Concepts are edited by Drew A Rosielle MD, Palliative Care Center, Medical College of Wisconsin. For more information write to: email@example.com. More information, as well as the complete set of Fast Facts, are available at EPERC: www.eperc.mcw.edu.
Version History: This Fast Fact was originally edited by David E Weissman MD. 2nd Edition was edited by Drew A Rosielle and published November 2007. Current version re-copy-edited April 2009.
Copyright/Referencing Information: Users are free to download and distribute Fast Facts for educational purposes only. Reisfield GM, Wilson GR. Blocks of the Sympathetic Axis for Visceral Pain. 2nd Edition. Fast Facts and Concepts. November 2007; 97. Available at: http://www.eperc.mcw.edu/EPERC/FastFactsIndex/ff_097.htm.
Disclaimer: Fast Facts and Concepts provide educational information. This information is not medical advice. Health care providers should exercise their own independent clinical judgment. Some Fast Facts cite the use of a product in a dosage, for an indication, or in a manner other than that recommended in the product labeling. Accordingly, the official prescribing information should be consulted before any such product is used.
ACGME Competencies: Medical Knowledge, Patient Care
Keyword(s): Pain – Opioids