Author(s): Richard Altman MD, Eric Milbrandt MD, MPH, and Robert Arnold MD
Background Delirium is an acute, fluctuating change in mental status, accompanied by sleep/wake cycle disruption, inattention, and altered perceptions (hallucinations/delusions) (see Fast Facts #1, 60). Delirium can be hypoactive or hyperactive. Patients with hypoactive delirium are calm, but inattentive and manifest decreased mobility. Patients with hyperactive delirium are agitated and combative, and also lack the ability to maintain attention to complete tasks. Delirium can be considered a marker of acute brain dysfunction, much like shock is evidence for dysfunction of the cardiovascular system (1).
ICU Delirium Delirium occurring in the ICU is associated with an increased length of hospitalization, increased need for institutionalization, and higher short and long-term mortality (2). In the ICU, delirium occurs in as many as 80% of patients, but is often overlooked or misdiagnosed because of the difficulty of assessing mental states in intubated patients. Three assessment tools have been described in the literature to aid in delirium diagnosis.
The Confusion Assessment Method-Intensive Care Unit (CAM-ICU) Assessment Tool is the best documented method of diagnosing delirium in the ICU (3). This tool was specifically designed for use in non-verbal (i.e. mechanically ventilated) patients. With the CAM-ICU, delirium is diagnosed when patients demonstrate 1) an acute change in mental status or fluctuating changes in mental status, 2) inattention measured using either an auditory or visual test, and either 3) disorganized thinking, or 4) an altered level of consciousness. Importantly, the CAM-ICU can only be administered if the patient is arousable to voice without the need for physical stimulation. The CAM-ICU includes very specific assessment questions/tools, found online at http://www.icudelirium.org/delirium/CAM-ICUTraining.html.
When administered by a nurse, the CAM-ICU takes only 1 to 2 minutes to conduct and has a minimum of 93% sensitivity and 89% specificity for detecting delirium as compared to full DSM-IV assessment by a geriatric psychiatrist (2,4). National guidelines recommend routine use of the CAM-ICU for delirium assessment in all critically ill patients and treatment with haloperidol when delirium is present (5). However, these recommendations are based on expert opinion and limited case series. It remains unknown whether diagnosis and/or treatment of delirium will lead to better patient outcomes. While there are some early observational cohort data suggesting that patients treated with haloperidol have lower hospital mortality, this finding needs confirmation in a randomized, controlled trial before being applied to routine patient care.
The Intensive Care Delirium Screening Checklist assesses eight features of delirium: altered level of consciousness, inattention, disorientation, hallucinations, psychomotor agitation/retardation, inappropriate mood/speech, sleep/wake cycle disturbance, and symptom fluctuation. The sensitivity and specificity of this tool were 99% and 64% respectively in one report (6).
The Delirium Screening Checklist is another recent tool that uses a checklist similar to the Intensive Care Delirium Screening Checklist (7).
Recommendation It is believed that prompt recognition and treatment of ICU delirium is important for patient safety. Use of rapid tools such as CAM-ICU can help identify ICU delirium and are recommended when assessing mental status changes. The benefit of routine use of these screening tools is yet to be tested.
Ely EW, Siegel MD, Inouye SK. Delirium in the Intensive Care Unit: An Under-Recognized Syndrome of Organ Dysfunction. Seminars in Respiratory & Critical Care Medicine. 2001; 22(2):115-126.
Ely EW, Inouye SK, Bernard GR, Gordon S, Francis J, May L, Truman B, Speroff T, Gautam S, Margolin R, Hart RP, Dittus R. Delirium in Mechanically Ventilated Patients: Validity and Reliability of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). JAMA. 2001; 286(21):2703-2710.
Ely EW, Truman B. The Confusion Assessment Method for the ICU (CAM-ICU) Training Manual. Available at: http://www.icudelirium.org/delirium/training-pages/CAM-ICU%20trainingman.2005.pdf. Accessed April 27, 2009.
Ely EW, Margolin R, Francis J, May L, Truman B, Dittus R, Speroff T, Gautam S, Bernard GR, Inouye SK. Evaluation of delirium in critically ill patients: validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Crit Care Med. 2001; 29:1370-9.
Jacobi J, Fraser GL, Coursin DB, et al. Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med. 2002; 30:119-41.
Bergeron N, Dubois MJ, Dumont M, Dial S, Skrobik Y. Intensive Care Delirium Screening Checklist: evaluation of a new screening tool. Intensive Care Med. 2001; 27:859-864
Otter H, Martin J, Basell K, von Heymann C, et al. Validity and reliability of the DDS for severity of delirium in the ICU. Neurocrit Care. 2005; 2(2):150-8.
Fast Facts and Concepts are edited by Drew A Rosielle MD, Palliative Care Center, Medical College of Wisconsin. For more information write to: firstname.lastname@example.org. More information, as well as the complete set of Fast Facts, are available at EPERC: www.eperc.mcw.edu.
Version History: This Fast Fact was originally edited by David E Weissman MD and published in August 2006. Current version re-copy-edited in April 2009.
Copyright/Referencing Information: Users are free to download and distribute Fast Facts for educational purposes only. Alman R, Millbrandt E, Arnold R. Screening for ICU Delirium. Fast Facts and Concepts. August 2006; 160. Available at: http://www.eperc.mcw.edu/EPERC/FastFactsIndex/ff_160.htm.
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